-The journal of the medical economic ,it is found that the burden of multiple sclerosis in health care in range between 8,500$ to 50,000$ and more annually ( the ordinally cost of illness from 8,000$ to 11,000$ and now the cost of illness about 60,000$ annually ) -the burden of multiple sclerosis still increase annually at range from 5 – 7 times and more than the prescription drug influence -now the new drug cost of modified treatment to multiple sclerosis is commonly enter market range from 25-60% higher than that of existed drug modified treatment-the direct medical cost to multiple sclerosis is range from less than 15,000 $– to higher than 50,000$ annuallythe cost of illness in united statue (us)-the multiple sclerosis affect nearly about 40,000 individual in the united statue and world wide -the cost of illness in 2008-2012 with multiple sclerosis is 4 billion is nearly 9 billion annually -in 1990: the burden of multiple sclerosis is approximately from 9,000 to 12,000 $ per patient annually , the price of agent continuous to grow and increase in price-in 2004 : average burden for a patient was 16,050$ , the total price of care and exploit of service increase not only with high and good effect but and also with increase of the cost average health care cost of moderate relapse intensity function and lack of ability is 30,000$ and with high relapse intensity and lack of ability cost 50,000$ and with sever lack of ability cost 100,000$ -in 2012: average patient cost of illness was 30,000$ annually as it various with severity -the pre-patient price is increase above 66,000$ annually the cost of illness in Egypt -multiple sclerosis occur in age above 17 years old , it is spread is 13,07-100,000 from all neurological diseases , number of patient with multiple sclerosis about approximately above 40,000 patient-patient who take treatment it is cost from 2,000$ to 3,000$ for 3-6 month for treatment -it was unfortunately some people are unable to buy for treatment because it is cost is high about 4,000$ that make them unable to continuous treatment -the cost of illness interfere treatment increased about 8% to 16% -in the world wide : multiple sclerosis affect about 2.5 million patient -multiple sclerosis found in middle east in 5 eastern countries